Dermatology : Vitiligo

Pseudocatalase Cream

Vitiligo is a spontaneous irregular depigmentation of skin. Patients with vitiligo have low catalase levels in their epidermis with high levels of hydrogen peroxide. Pseudocatalase cream is an externally applied UVB-activated product that can lead to recovery of the oxidative damage in the epidermis and remarkable repigmentation.

Skin Pharmacol Appl Skin Physiol 1999 May-Jun;12(3):132-8 Click here to access the PubMed abstract

J Pathol 2000 Aug;191(4):407-16 Click here to access the PubMed abstract

J Investig Dermatol Symp Proc 1999 Sep;4(1):91-6 Click here to access the PubMed abstract

Dermatology 1995;190(3):223-9 Click here to access the PubMed abstract

Topical Phenylalanine

Melanocytes are still present in long-standing (> 25 years) depigmented skin of patients with vitiligo. L-phenylalanine uptake and turnover in the pigment forming melanocytes is vital for initiation of melanogenesis.

Arch Dermatol. 1999;135:216-217 Click here to access the PubMed abstract

J Drugs Dermatol 2002 Sep;1(2):127-31 Click here to access the PubMed abstract

Mol Genet Metab 2005 Dec;86(4):27-33 Click here to access the PubMed abstract